Creative Biomart’s HostOptimTM boosts recombinant protein production per cell by increasing the protein per mRNA ratio across a range of eukaryotic production hosts.

HostOptimTM technology can be used to increase the production yield of recombinant protein and can be combined with transcription enhancing or other production improving technologies. Thus you mammalian expression system can be applied in:

1. Antigens and Ligands: for immunization and affinity purification of antibodies developed; 2. Protein Standards: ELISA calibrators, mass spectrometry references, activity measures, and functional controls; 3. Application Assays: Specific function measurement, enzymatic reactions, nuclear magnetic resonance imaging, protein-protein interactions, high-throughput screening, dye-binding assays, neutralization, and affinity determination; 4. Cell Based Assays: Proliferation assays, apoptosis assays, and hybridoma screening; 5. Clinical Products: Therapeutics and vaccines.

And the proteins produced in mammalian system have the best structural and functional features that are usually most close to their cognate native form and can satisfy the following application needs or utility:

 Transgene expression  Biochemical analyses  Assay standards  Functional studies of the protein (in vitro and ex vivo)  Structural studies, including protein crystallization, protein structure and NMR  Protein-protein interaction experiments  Enzyme kinetics Immunogen for antibodies development  Proteomic and phenomics study  Drug target discovery and validation  Cell line development, drug screening, and in vitro model system  Animal studies, including in vivo functional and ADME, PK/TK and safety studies  Physiology and pathology studies  Diagnostic application  Therapeutic application  Prophylactic (vaccine) development Protein engineering and mutagenesis studies

Creative Biomart is glad to introduce the novel technology to you here. As a leading protein expression services supplier, Creative Biomart will find you a perfect solution. For more information, visit

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